Conditional knockout of N-WASP enhanced the formation of keratinizing squamous cell carcinoma induced by KRasG12D

• Main Authors: Kalailingam, Pazhanichamy, Verma, Apoorva, Lee, Ying Hui, Thanabalu, Thirumaran
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Science::Biological sciences; Keratin Pearl; Skin Cancer
• Online Access: https://hdl.handle.net/10356/173146
• Institution: Nanyang Technological University

Squamous cell carcinoma (SCC) is one of the most common forms of skin cancer in humans, and Neural Wiskott-Aldrich Syndrome Protein (N-WASP) plays a crucial role in epidermal homeostasis. To elucidate the role of N-WASP in skin cancer, we generated mice which expressed constitutively active KRas (KR...