Assessing the permeability of supersaturating drug delivery system of amorphous drug-polyelectrolyte/protein nanoplexes in Caco-2 cell monolayer

• Main Authors: Tran, The-Thien, Cheow, Wean Sin, Chua, Angeline, Yang, Guang, Poenar, Daniel Puiu, Hadinoto, Kunn
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Engineering::Bioengineering; Amorphous Pharmaceuticals; Drug Nanoparticles
• Online Access: https://hdl.handle.net/10356/173291
• Institution: Nanyang Technological University

Solubility enhancements of amorphous drug-polyelectrolyte and drug-protein nanoparticle complexes (nanoplexes) by virtue of their supersaturation generation were established previously. Their permeability across intestinal membrane, however, had not been assessed. The present work evaluated the memb...