Controlling the burst release of amorphous drug–polysaccharide nanoparticle complex via crosslinking of the polysaccharide chains

• Main Authors: Nguyen, Minh-Hiep, Tran, The-Thien, Hadinoto, Kunn
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: Amorphization; Drug–polysaccharide complex
• Online Access: https://hdl.handle.net/10356/82276; http://hdl.handle.net/10220/41174
• Institution: Nanyang Technological University

High-payload amorphous drug–polysaccharide nanoparticle complex (or nanoplex in short) represents a new class of supersaturating drug delivery systems intended for bioavailability enhancement of poorly-soluble drugs. Not unlike other nanoscale amorphous formulations, the nanoplex exhibits fast disso...