Millifluidic synthesis of amorphous drug-polysaccharide nanoparticle complex with tunable size intended for supersaturating drug delivery applications

• Main Authors: Tran, The-Thien, Nguyen, Minh-Hiep, Tan, Yong Zen, Chew, Jia Wei, Khan, Saif A., Hadinoto, Kunn
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: Millifluidics; Microfluidics
• Online Access: https://hdl.handle.net/10356/84720; http://hdl.handle.net/10220/41931
• Institution: Nanyang Technological University

The conventional bulk mixing method to prepare amorphous drug-polysaccharide nanoparticle complex (or drug nanoplex in short) has a major drawback in the lack of size control for the nanoplex produced, hence limiting its potential applications as a supersaturating drug delivery system for bioavailab...