Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish

Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish

Mycobacterium abscessus is a non-tuberculous mycobacterium (NTM) that causes chronic pulmonary infections. Because of its extensive innate resistance to numerous antibiotics, treatment options are limited, often resulting in poor clinical outcomes. Current treatment regimens usually involve a combin...

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Bibliographic Details
Main Authors: Goh, Boon Chong, Larsson, Simon, Dam, Linh Chi, Ling, Sharon Yan Han, Chua, Patrina Wei Lin, Abirami, R., Singh, Samsher, Ong, Ernest Jun Long, Teo, Jeanette W. P., Ho, Peiying, Ingham, Philip William, Pethe, Kevin, Dedon, Peter C.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Antibiotics
Clarithromycin
Online Access:https://hdl.handle.net/10356/173643
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Institution: Nanyang Technological University
Language: English
Description
Summary:Mycobacterium abscessus is a non-tuberculous mycobacterium (NTM) that causes chronic pulmonary infections. Because of its extensive innate resistance to numerous antibiotics, treatment options are limited, often resulting in poor clinical outcomes. Current treatment regimens usually involve a combination of antibiotics, with clarithromycin being the cornerstone of NTM treatments.

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