Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes
A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented, providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio- and stereoselectivities. The reaction is performed under mild condition...
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sg-ntu-dr.10356-1737442024-03-01T15:31:44Z Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes He, Yimiao Yuan, Jingwen Lv, Wen-Xin Liu, Peng Teng, Fan Mo, Qijin Wu, Zihua Huang, Chusheng Liu, Qianwen Wang, Honggen School of Chemistry, Chemical Engineering and Biotechnology Chemistry Gem-difluorocyclopropene Ring-opening defluorination A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented, providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio- and stereoselectivities. The reaction is performed under mild conditions with no need of using an excess amount of nucleophilic reagents. Water plays a crucial role in this transformation. Published version This work was financially supported by the National Natural Science Foundation of China (Nos. 21861007 and 21702034), Natural Science Foundation of Guangxi Province (Nos. 2021GXNSFAA075024 and 2 022GXNSFAA035468), the Guangdong Basic and Applied Basic Research Foundation (No. 2020A1515010624), Natural Science Foundation of Jiangxi Province of China (No. 20212BAB213024), “BAGUI Scholar” Program of Guangxi Province of China. 2024-02-26T05:41:14Z 2024-02-26T05:41:14Z 2024 Journal Article He, Y., Yuan, J., Lv, W., Liu, P., Teng, F., Mo, Q., Wu, Z., Huang, C., Liu, Q. & Wang, H. (2024). Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes. Green Synthesis and Catalysis, 5(1), 14-19. https://dx.doi.org/10.1016/j.gresc.2023.01.003 2666-5549 https://hdl.handle.net/10356/173744 10.1016/j.gresc.2023.01.003 2-s2.0-85148742801 1 5 14 19 en Green Synthesis and Catalysis © 2023 Fudan University. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). application/pdf |
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Chemistry Gem-difluorocyclopropene Ring-opening defluorination |
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Chemistry Gem-difluorocyclopropene Ring-opening defluorination He, Yimiao Yuan, Jingwen Lv, Wen-Xin Liu, Peng Teng, Fan Mo, Qijin Wu, Zihua Huang, Chusheng Liu, Qianwen Wang, Honggen Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes |
| description |
A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented, providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio- and stereoselectivities. The reaction is performed under mild conditions with no need of using an excess amount of nucleophilic reagents. Water plays a crucial role in this transformation. |
| author2 |
School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet |
School of Chemistry, Chemical Engineering and Biotechnology He, Yimiao Yuan, Jingwen Lv, Wen-Xin Liu, Peng Teng, Fan Mo, Qijin Wu, Zihua Huang, Chusheng Liu, Qianwen Wang, Honggen |
| format |
Article |
| author |
He, Yimiao Yuan, Jingwen Lv, Wen-Xin Liu, Peng Teng, Fan Mo, Qijin Wu, Zihua Huang, Chusheng Liu, Qianwen Wang, Honggen |
| author_sort |
He, Yimiao |
| title |
Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes |
| title_short |
Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes |
| title_full |
Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes |
| title_fullStr |
Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes |
| title_full_unstemmed |
Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes |
| title_sort |
simple nucleophile/h₂o promoted defluorinative ring-opening of gem-difluorocyclopropenes |
| publishDate |
2024 |
| url |
https://hdl.handle.net/10356/173744 |
| _version_ |
1794549336124686336 |