Simple nucleophile/H₂O promoted defluorinative ring-opening of gem-difluorocyclopropenes

• Main Authors: He, Yimiao, Yuan, Jingwen, Lv, Wen-Xin, Liu, Peng, Teng, Fan, Mo, Qijin, Wu, Zihua, Huang, Chusheng, Liu, Qianwen, Wang, Honggen
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Gem-difluorocyclopropene; Ring-opening defluorination
• Online Access: https://hdl.handle.net/10356/173744
• Institution: Nanyang Technological University

A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented, providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio- and stereoselectivities. The reaction is performed under mild condition...