FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons

FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons

MicroRNAs (miRNAs) modulate mRNA expression, and their deregulation contributes to various diseases including amyotrophic lateral sclerosis (ALS). As fused in sarcoma (FUS) is a causal gene for ALS and regulates biogenesis of miRNAs, we systematically analyzed the miRNA repertoires in spinal cords a...

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Main Authors: Ho, Wan Yun, Chak, Li-Ling, Hor, Jin-Hui, Liu, Fujia, Diaz-Garcia, Sandra, Chang, Jer-Cherng, Sanford, Emma, Rodriguez, Maria J., Alagappan, Durgadevi, Lim, Su Min, Cho, Yik-Lam, Shimizu, Yuji, Sun, Alfred Xuyang, Tyan, Sheue-Houy, Koo, Edward, Kim, Seung Hyun, Ravits, John, Ng, Shi-Yan, Okamura, Katsutomo, Ling, Shuo-Chien
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Cellular neuroscience
Natural sciences
Online Access:https://hdl.handle.net/10356/173808
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/173808

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