Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

• Main Authors: Mok, Sachel, Yeo, Tomas, Hong, Davin, Shears, Melanie J., Ross, Leila S., Ward, Kurt E., Dhingra, Satish K., Kanai, Mariko, Bridgford, Jessica L., Tripathi, Abhai K., Mlambo, Godfree, Burkhard, Anna Y., Ansbro, Megan R., Fairhurst, Kate J., Gil-Iturbe, Eva, Park, Heekuk, Rozenberg, Felix D., Kim, Jonathan, Mancia, Filippo, Fairhurst, Rick M., Quick, Matthias, Uhlemann, Anne-Catrin, Sinnis, Photini, Fidock, David A.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Drug resistance; Genetics
• Online Access: https://hdl.handle.net/10356/173815
• Institution: Nanyang Technological University

Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we report the identification of key determinants of resistance to artemisinin (ART) and piperaquine (PPQ) in the dominant Asian...