Design and evaluation of tadpole-like conformational antimicrobial peptides

• Main Authors: Tang, Ziyi, Jiang, Wuqiao, Li, Shuangli, Huang, Xue, Yang, Yi, Chen, Xiaorong, Qiu, Jingyi, Xiao, Chuyu, Xie, Ying, Zhang, Xu, Li, Jianguo, Verma, Chandra Shekhar, He, Yun, Yang, Aimin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Antiinfective agent; Polypeptide antibiotic agent
• Online Access: https://hdl.handle.net/10356/173870
• Institution: Nanyang Technological University

Antimicrobial peptides are promising alternatives to conventional antibiotics. Herein, we report a class of "tadpole-like" peptides consisting of an amphipathic α-helical head and an aromatic tail. A structure-activity relationship (SAR) study of "tadpole-like" temporin-SHf and i...