Metabolism of glucose activates TORC1 through multiple mechanisms in Saccharomyces cerevisiae

• Main Authors: Alfatah, Mohammad, Cui, Liang, Goh, Corinna Jie Hui, Cheng, Trishia Yi Ning, Zhang, Yizhong, Naaz, Arshia, Wong, Jin Huei, Lewis, Jacqueline, Poh, Wei Jie, Arumugam, Prakash
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Glucose signaling; Glycolysis
• Online Access: https://hdl.handle.net/10356/173930
• Institution: Nanyang Technological University

Target of Rapamycin Complex 1 (TORC1) is a conserved eukaryotic protein complex that links the presence of nutrients with cell growth. In Saccharomyces cerevisiae, TORC1 activity is positively regulated by the presence of amino acids and glucose in the medium. However, the mechanisms underlying nutr...