COVID-19 severity and waning immunity after up to 4 mRNA vaccine doses in 73 608 patients with cancer and 621 475 matched controls in Singapore: a nationwide cohort study

• Main Authors: Tan, Wei Chong, Tan, Janice Yu Jin, Lim, Joline Si Jing, Tan, Ryan Ying Cong, Lee, Ainsley Ryan Yan Bin, Leong, Fun Loon, Lee, Soo Chin, Chai, Louis Yi Ann, Tan, Thuan Tong, Muhammad Ismail Bin Abdul Malek, Ong, Benjamin, Lye, David C., Chiew, Calvin J., Chng, Wee Joo, Lim, Soon Thye, Bharwani, Lavina D., Tan, Iain Bee Huat, Sundar, Raghav, Tan, Kelvin Bryan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; SARS-CoV-2 vaccine; Immune response
• Online Access: https://hdl.handle.net/10356/174182
• Institution: Nanyang Technological University

Importance: Despite patients with cancer being at risk of poor outcomes from COVID-19, there are few published studies for vaccine efficacy in this group, with suboptimal immunogenicity and waning vaccine efficacy described in small studies being a concern. Objective: To assess the incidence rate of...