A closer look at ligand specificity for cellular activation of NOD2 with synthetic muramyl dipeptide analogues

• Main Authors: Adamson, Christopher, Liang, Yaquan, Feng, Shiliu, Ng, Allan Wee Ren, Qiao, Yuan
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Ligands; Peptides
• Online Access: https://hdl.handle.net/10356/174232
• Institution: Nanyang Technological University

To further understand the specificity of muramyl dipeptide (MDP) sensing by NOD2, we evaluated the compatibility of synthetic MDP analogues for cellular uptake and NAGK phosphorylation, the pre-requisite steps of intracellular NOD2 activation. Our results revealed that these two prior steps do not c...