Multigenerational adversity impacts on human gut microbiome composition and socioemotional functioning in early childhood

• Main Authors: Querdasi, Francesca R., Enders, Craig, Karnani, Neerja, Broekman, Birit, Chong, Yap Seng, Gluckman, Peter D., Daniel, Lourdes Mary, Yap, Fabian, Eriksson, Johan G., Cai, Shirong, Chong, Mary Foong-Fong, Toh, Jia Ying, Godfrey, Keith, Meaney, Michael J., Callaghan, Bridget L.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Intergenerational transmission; Early life adversity
• Online Access: https://hdl.handle.net/10356/174264
• Institution: Nanyang Technological University

Adversity exposures in the prenatal and postnatal period are associated with an increased risk for psychopathology, which can be perpetuated across generations. Nonhuman animal research highlights the gut microbiome as a putative biological mechanism underlying such generational risks. In a sample of 450 mother-child dyads living in Singapore, we examined associations between three distinct adversity exposures experienced across two generations-maternal childhood maltreatment, maternal prenatal anxiety, and second-generation children's exposure to stressful life events-and the gut microbiome composition of second-generation children at 2 y of age. We found distinct differences in gut microbiome profiles linked to each adversity exposure, as well as some nonaffected microbiome features (e.g., beta diversity). Remarkably, some of the microbial taxa associated with concurrent and prospective child socioemotional functioning shared overlapping putative functions with those affected by adversity, suggesting that the intergenerational transmission of adversity may have a lasting impact on children's mental health via alterations to gut microbiome functions. Our findings open up a new avenue of research into the underlying mechanisms of intergenerational transmission of mental health risks and the potential of the gut microbiome as a target for intervention.