Plasmodium falciparum eukaryotic translation initiation factor 3 is stabilized by quinazoline-quinoline bisubstrate inhibitors

• Main Authors: Dobrescu, Irina, Hammam, Elie, Dziekan, Jerzy Michal, Claës, Aurélie, Halby, Ludovic, Preiser, Peter, Bozdech, Zbynek, Arimondo, Paola B., Scherf, Artur, Nardella, Flore
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Malaria; Bisubstrate inhibitors
• Online Access: https://hdl.handle.net/10356/174270
• Institution: Nanyang Technological University

Malaria drug resistance is hampering the fight against the deadliest parasitic disease affecting over 200 million people worldwide. We recently developed quinoline-quinazoline-based inhibitors (as compound 70) as promising new antimalarials. Here, we aimed to investigate their mode of action by usin...