Gut bacterial metabolism contributes to host global purine homeostasis

• Main Authors: Kasahara, Kazuyuki, Kerby, Robert L., Zhang, Qijun, Pradhan, Meenakshi, Mehrabian, Margarete, Lusis, Aldons J., Bergström, Göran, Bäckhed, Fredrik, Rey, Federico E.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Atherosclerosis; Gut microbiome
• Online Access: https://hdl.handle.net/10356/174279
• Institution: Nanyang Technological University

The microbes and microbial pathways that influence host inflammatory disease progression remain largely undefined. Here, we show that variation in atherosclerosis burden is partially driven by gut microbiota and is associated with circulating levels of uric acid (UA) in mice and humans. We identify...