Longitudinal profiling and tracking stability in the Singapore study of macro-angiopathy and microvascular reactivity in type 2 diabetes cohort

• Main Authors: Low, Serena, Zheng, Huili, Liu, Jian-Jun, Moh, Angela, Ang, Keven, Tang, Wern Ee, Lim, Ziliang, Subramaniam, Tavintharan, Sum, Chee Fang, Lim, Su Chi
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Calibration; Stability
• Online Access: https://hdl.handle.net/10356/174289
• Institution: Nanyang Technological University

The Singapore Study of Macro-Angiopathy and microvascular Reactivity in Type 2 Diabetes (SMART2D) is a prospective cohort study which was started in 2011 to investigate the effect of risk factors on vascular function and diabetes-related complications in Asians. We aimed to compare the longitudinal change in risk factors by accounting for batch effect and assess the tracking stability of risk factors over time in patients recruited for SMART2D. In this study, we (1) described batch effect and its extent across a heterogenous range of longitudinal data parameters; (2) mitigated batch effect through statistical approach; and (3) assessed the tracking stability of the risk factors over time.