Dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver

Obese white adipose tissue (WAT) is characterized by hypoxia, oxidative stress, and inflammation, which are the key drivers of various deleterious diseases. Herein, we demonstrate a new strategy to directly induce ameliorative remodeling of obese subcutaneous WAT (sWAT). Manganese dioxide nanopartic...

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Main Authors: Zan, Ping, Than, Aung, Leow, Melvin Khee-Shing, Cai, Helen Xinyi, Wen, Hanqi, Zhang, Zheye, Chen, Peng
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2024
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Online Access:https://hdl.handle.net/10356/174661
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1746612024-04-12T15:32:21Z Dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver Zan, Ping Than, Aung Leow, Melvin Khee-Shing Cai, Helen Xinyi Wen, Hanqi Zhang, Zheye Chen, Peng School of Chemistry, Chemical Engineering and Biotechnology Lee Kong Chian School of Medicine (LKCMedicine) Institute for Digital Molecular Analytics and Science (IDMxS) Medicine, Health and Life Sciences Obesity Metabolic disease Obese white adipose tissue (WAT) is characterized by hypoxia, oxidative stress, and inflammation, which are the key drivers of various deleterious diseases. Herein, we demonstrate a new strategy to directly induce ameliorative remodeling of obese subcutaneous WAT (sWAT). Manganese dioxide nanoparticle, which can directly react with hydrogen peroxide and produce oxygen, and has nanocatalytic abilities mimicking superoxide dismutase and catalase, is transdermally delivered together with a natural antioxidant resveratrol, leading to reduction of oxidative stress, hypoxia, and consequently suppression of inflammation in obese sWAT. The localized treatment not only leads to remodeling of the targeted sWAT and large reduction of its mass, but also improves whole-body metabolism as evidenced by total relief of diabetes, and significant decrease of visceral fat, liver fat, hyperlipidemia, and systemic inflammation. For self-administrable and minimally-invasive transdermal delivery, a new type of microneedle is designed, which is made purely by dry powders of the therapeutics and offers a loading capacity 2 orders higher than the conventional microneedles. Moreover, the intricate signaling pathways underlying this transdermal anti-inflammatory therapy are revealed. Ministry of Education (MOE) Ministry of Health (MOH) National Medical Research Council (NMRC) Submitted/Accepted version This work was financially supported by Singapore Ministry of Education under its Academic Research Fund (AcRF) Tier-1 grant (RT02/20 and RG27/23) and AcRF Tier-2 grant (MOE2019-T2-2004) and Singapore Ministry of Health under its National Medical Research Council - Clinician Scientist Award (MOH-001364). 2024-04-07T04:09:29Z 2024-04-07T04:09:29Z 2024 Journal Article Zan, P., Than, A., Leow, M. K., Cai, H. X., Wen, H., Zhang, Z. & Chen, P. (2024). Dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver. Chemical Engineering Journal, 484, 149395-. https://dx.doi.org/10.1016/j.cej.2024.149395 1385-8947 https://hdl.handle.net/10356/174661 10.1016/j.cej.2024.149395 2-s2.0-85185179774 484 149395 en RT02/20 RG27/23 MOE2019-T2-2004 MOH-001364 Chemical Engineering Journal © 2024 Elsevier B.V. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1016/j.cej.2024.149395. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Medicine, Health and Life Sciences
Obesity
Metabolic disease
spellingShingle Medicine, Health and Life Sciences
Obesity
Metabolic disease
Zan, Ping
Than, Aung
Leow, Melvin Khee-Shing
Cai, Helen Xinyi
Wen, Hanqi
Zhang, Zheye
Chen, Peng
Dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver
description Obese white adipose tissue (WAT) is characterized by hypoxia, oxidative stress, and inflammation, which are the key drivers of various deleterious diseases. Herein, we demonstrate a new strategy to directly induce ameliorative remodeling of obese subcutaneous WAT (sWAT). Manganese dioxide nanoparticle, which can directly react with hydrogen peroxide and produce oxygen, and has nanocatalytic abilities mimicking superoxide dismutase and catalase, is transdermally delivered together with a natural antioxidant resveratrol, leading to reduction of oxidative stress, hypoxia, and consequently suppression of inflammation in obese sWAT. The localized treatment not only leads to remodeling of the targeted sWAT and large reduction of its mass, but also improves whole-body metabolism as evidenced by total relief of diabetes, and significant decrease of visceral fat, liver fat, hyperlipidemia, and systemic inflammation. For self-administrable and minimally-invasive transdermal delivery, a new type of microneedle is designed, which is made purely by dry powders of the therapeutics and offers a loading capacity 2 orders higher than the conventional microneedles. Moreover, the intricate signaling pathways underlying this transdermal anti-inflammatory therapy are revealed.
author2 School of Chemistry, Chemical Engineering and Biotechnology
author_facet School of Chemistry, Chemical Engineering and Biotechnology
Zan, Ping
Than, Aung
Leow, Melvin Khee-Shing
Cai, Helen Xinyi
Wen, Hanqi
Zhang, Zheye
Chen, Peng
format Article
author Zan, Ping
Than, Aung
Leow, Melvin Khee-Shing
Cai, Helen Xinyi
Wen, Hanqi
Zhang, Zheye
Chen, Peng
author_sort Zan, Ping
title Dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver
title_short Dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver
title_full Dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver
title_fullStr Dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver
title_full_unstemmed Dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver
title_sort dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver
publishDate 2024
url https://hdl.handle.net/10356/174661
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