Dry powder microneedle-enabled transdermal anti-inflammatory therapy for obesity, diabetes, hyperlipidemia, and fatty liver

• Main Authors: Zan, Ping, Than, Aung, Leow, Melvin Khee-Shing, Cai, Helen Xinyi, Wen, Hanqi, Zhang, Zheye, Chen, Peng
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Obesity; Metabolic disease
• Online Access: https://hdl.handle.net/10356/174661
• Institution: Nanyang Technological University

Obese white adipose tissue (WAT) is characterized by hypoxia, oxidative stress, and inflammation, which are the key drivers of various deleterious diseases. Herein, we demonstrate a new strategy to directly induce ameliorative remodeling of obese subcutaneous WAT (sWAT). Manganese dioxide nanopartic...