Hydroalkylation of 1,1-diarylalkenes mediated by magnesium hydride in ethereal solvents
A method for the hydroalkylation of 1,1-diarylalkenes has been developed using magnesium hydride (MgH2) generated in situ by the solvothermal treatment of magnesium iodide (MgI2) with sodium hydride (NaH) in ethereal solvents. The process is initiated by the hydromagnesiation of 1,1-diarylalkenes wi...
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sg-ntu-dr.10356-1746692024-04-12T15:31:58Z Hydroalkylation of 1,1-diarylalkenes mediated by magnesium hydride in ethereal solvents Chaisan, Nattawadee Tan, Eugene Yew Kun Chiba, Shunsuke School of Chemistry, Chemical Engineering and Biotechnology Chemistry Hydroalkylation Magnesium hydride A method for the hydroalkylation of 1,1-diarylalkenes has been developed using magnesium hydride (MgH2) generated in situ by the solvothermal treatment of magnesium iodide (MgI2) with sodium hydride (NaH) in ethereal solvents. The process is initiated by the hydromagnesiation of 1,1-diarylalkenes with MgH2 to generate 1,1-diarylethylmagnesium species, which are immediately alkylated with ethereal solvents to construct a diaryl quaternary carbon center in the hydroalkylation products. Ministry of Education (MOE) Nanyang Technological University Submitted/Accepted version This work was financially supported by Nanyang Technological University (NTU) and the Singapore Ministry of Education (Academic Research Fund Tier 2: MOE2019-T2-1-089) for S.C. 2024-04-07T06:57:31Z 2024-04-07T06:57:31Z 2024 Journal Article Chaisan, N., Tan, E. Y. K. & Chiba, S. (2024). Hydroalkylation of 1,1-diarylalkenes mediated by magnesium hydride in ethereal solvents. Helvetica Chimica Acta, 107(2), e202300212-. https://dx.doi.org/10.1002/hlca.202300212 0018-019X https://hdl.handle.net/10356/174669 10.1002/hlca.202300212 2-s2.0-85182408217 2 107 e202300212 en MOE2019-T2-1-089 Helvetica Chimica Acta © 2023 Wiley-VHCA AG, Zurich, Switzerland. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1002/hlca.202300212. application/pdf |
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Nanyang Technological University |
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English |
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Chemistry Hydroalkylation Magnesium hydride |
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Chemistry Hydroalkylation Magnesium hydride Chaisan, Nattawadee Tan, Eugene Yew Kun Chiba, Shunsuke Hydroalkylation of 1,1-diarylalkenes mediated by magnesium hydride in ethereal solvents |
| description |
A method for the hydroalkylation of 1,1-diarylalkenes has been developed using magnesium hydride (MgH2) generated in situ by the solvothermal treatment of magnesium iodide (MgI2) with sodium hydride (NaH) in ethereal solvents. The process is initiated by the hydromagnesiation of 1,1-diarylalkenes with MgH2 to generate 1,1-diarylethylmagnesium species, which are immediately alkylated with ethereal solvents to construct a diaryl quaternary carbon center in the hydroalkylation products. |
| author2 |
School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet |
School of Chemistry, Chemical Engineering and Biotechnology Chaisan, Nattawadee Tan, Eugene Yew Kun Chiba, Shunsuke |
| format |
Article |
| author |
Chaisan, Nattawadee Tan, Eugene Yew Kun Chiba, Shunsuke |
| author_sort |
Chaisan, Nattawadee |
| title |
Hydroalkylation of 1,1-diarylalkenes mediated by magnesium hydride in ethereal solvents |
| title_short |
Hydroalkylation of 1,1-diarylalkenes mediated by magnesium hydride in ethereal solvents |
| title_full |
Hydroalkylation of 1,1-diarylalkenes mediated by magnesium hydride in ethereal solvents |
| title_fullStr |
Hydroalkylation of 1,1-diarylalkenes mediated by magnesium hydride in ethereal solvents |
| title_full_unstemmed |
Hydroalkylation of 1,1-diarylalkenes mediated by magnesium hydride in ethereal solvents |
| title_sort |
hydroalkylation of 1,1-diarylalkenes mediated by magnesium hydride in ethereal solvents |
| publishDate |
2024 |
| url |
https://hdl.handle.net/10356/174669 |
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1800916257688518656 |