Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma

Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma

In multiple myeloma, abnormal plasma cells establish oncogenic niches within the bone marrow by engaging the NF-κB pathway to nurture their survival while they accumulate pro-proliferative mutations. Under these conditions, many cases eventually develop genetic abnormalities endowing them with const...

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Bibliographic Details
Main Authors: Ang, Daniel Aron, Carter, Jean-Michel, Deka, Kamalakshi, Tan, Joel H. L., Zhou, Jianbiao, Chen, Qingfeng, Chng, Wee Joo, Harmston, Nathan, Li, Yinghui
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Cancer growth
Carcinogenesis
Online Access:https://hdl.handle.net/10356/174697
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/174697

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