Utilizing molecular docking and cell validation to explore the potential mechanisms of lupenone attenuating the inflammatory response via NF-κB pathway

• Main Authors: Wang, Xiangpei, Liu, Mei, Li, Xiaofen, Zhang, Mei, Xu, Feng, Liu, Hongyun, Wu, Hongmei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Antiinflammatory agent; Cytokine
• Online Access: https://hdl.handle.net/10356/174953
• Institution: Nanyang Technological University

Diabetic nephropathy (DN), a common microvascular complicating disease of diabetes. Lupenone, a pentacyclic triterpenoid, has anti-inflammatory effects and can prevent type 2 diabetes mellitus and treat renal damage, however, the effects and mechanisms of lupenone in DN remain unclear. Thereby,the M...