An allosteric mechanism for potent inhibition of SARS-CoV-2 main proteinase

• Main Authors: Zhang, Yunju, Guo, Jingjing, Liu, Yang, Qu, Yuanyuan, Li, Yong-Qiang, Mu, Yuguang, Li, Weifeng
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; SARS-CoV-2 main proteinase; Allosteric inhibitor
• Online Access: https://hdl.handle.net/10356/175836
• Institution: Nanyang Technological University

The main proteinase (Mpro) of SARS-CoV-2 plays a critical role in cleaving viral polyproteins into functional proteins required for viral replication and assembly, making it a prime drug target for COVID-19. It is well known that noncompetitive inhibition offers potential therapeutic options for tre...