Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity

• Main Authors: Siti Naqiah Amrun, Lee, Cheryl Yi-Pin, Lee, Bernett, Fong, Siew-Wai, Young, Barnaby Edward, Chee, Rhonda Sin-Ling, Yeo, Nicholas Kim-Wah, Torres-Ruesta, Anthony, Carissimo, Guillaume, Poh, Chek Meng, Chang, Zi Wei, Tay, Matthew Zirui, Chan, Yi-Hao, Chen, Mark I-Cheng, Low, Jenny Guek-Hong, Tambyah, Paul A., Kalimuddin, Shirin, Pada, Surinder, Tan, Seow-Yen, Sun, Louisa Jin, Leo, Yee-Sin, Lye, David C., Renia, Laurent, Ng, Lisa F. P.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Epitopes; SARS-CoV-2
• Online Access: https://hdl.handle.net/10356/145439
• Institution: Nanyang Technological University

Background: Given the unceasing worldwide surge in COVID-19 cases, there is an imperative need to develop highly specific and sensitive serology assays to define exposure to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Methods: Pooled plasma samples from PCR positive COVID-19 patien...