Ultrafast biomimetic oxidative folding of cysteine-rich peptides and microproteins in organic solvents

• Main Authors: Kam, Antony, Loo, Shining, Qiu, Yibo, Liu, Chuan-Fa, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Oxidative folding; Cysteine-rich peptides
• Online Access: https://hdl.handle.net/10356/175867
• Institution: Nanyang Technological University

Disulfides in peptides and proteins are essential for maintaining a properly folded structure. Their oxidative folding is invariably performed in an aqueous-buffered solution. However, this process is often slow and can lead to misfolded products. Here, we report a novel concept and strategy that is...