Nontoxic, biodegradable hyperbranched poly(β-amino ester)s for efficient siRNA delivery and gene silencing

• Main Authors: Ooi, Ying Jie, Huang, Chongquan, Lau, Kieran, Chew, Sing Yian, Park, Jong Gu, Chan-Park, Mary B.
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Gene silencing; Primary neural cells
• Online Access: https://hdl.handle.net/10356/176048
• Institution: Nanyang Technological University

RNA interference (RNAi)-mediated gene silencing is a promising therapeutic approach to treat various diseases, but safe and efficient delivery remains a major challenge to its clinical application. Non-viral gene vectors, such as poly(β-amino esters) (pBAEs), have emerged as a potential candidate du...