In situ mitochondrial biomineralization for drug-free cancer therapy

The common clinical chemotherapy often brings serious side effects to patients, mainly due to the off-target and leakage of toxic drugs. However, this is fatal for some specific clinical tumors, such as brain tumors and neuroma. This study performs a drug-free approach by encapsulating black phospho...

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Main Authors: Ma, Zhaoyu, Zeng, Pei, Zhai, Tianyou, Zhao, Yanli, Liang, Huageng
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2024
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Online Access:https://hdl.handle.net/10356/177912
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1779122024-06-03T04:29:03Z In situ mitochondrial biomineralization for drug-free cancer therapy Ma, Zhaoyu Zeng, Pei Zhai, Tianyou Zhao, Yanli Liang, Huageng School of Chemistry, Chemical Engineering and Biotechnology Medicine, Health and Life Sciences Calcification Cancer therapy The common clinical chemotherapy often brings serious side effects to patients, mainly due to the off-target and leakage of toxic drugs. However, this is fatal for some specific clinical tumors, such as brain tumors and neuroma. This study performs a drug-free approach by encapsulating black phosphorus (BP) and calcium peroxide (CaO2) in liposomes with surface-modified triphenylphosphonium (BCLT) to develop mitochondria targeting calcification for cancer therapy without damaging normal cells. BCLT preferentially accumulates inside tumor mitochondria and then is activated by near-infrared (NIR) laser irradiation to produce abundant PO4 3- and Ca2+ to accelerate in situ mitochondrial mineralization, leading to mitochondrial dysfunction and cancer cell death. More importantly, both PO4 3- and Ca2+ are essential components of metabolism in the body, and random gradient diffusion or premature leakage does not cause damage to adjacent normal cells. This achievement promises to be an alternative to conventional chemotherapy in clinical practice for many specific tumor types. National Research Foundation (NRF) This work was supported by the National Natural Science Foundation of China (81927807 and 12174136). This work was also supported by the Singapore National Research Foundation under Its Competitive Research Programme (NRF-CRP26-2021-0002). 2024-06-03T04:29:03Z 2024-06-03T04:29:03Z 2024 Journal Article Ma, Z., Zeng, P., Zhai, T., Zhao, Y. & Liang, H. (2024). In situ mitochondrial biomineralization for drug-free cancer therapy. Advanced Materials, 36(19), e2310218-. https://dx.doi.org/10.1002/adma.202310218 0935-9648 https://hdl.handle.net/10356/177912 10.1002/adma.202310218 38315577 2-s2.0-85184728325 19 36 e2310218 en NRF-CRP26-2021-0002 Advanced Materials © 2024 Wiley-VCH GmbH. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Medicine, Health and Life Sciences
Calcification
Cancer therapy
spellingShingle Medicine, Health and Life Sciences
Calcification
Cancer therapy
Ma, Zhaoyu
Zeng, Pei
Zhai, Tianyou
Zhao, Yanli
Liang, Huageng
In situ mitochondrial biomineralization for drug-free cancer therapy
description The common clinical chemotherapy often brings serious side effects to patients, mainly due to the off-target and leakage of toxic drugs. However, this is fatal for some specific clinical tumors, such as brain tumors and neuroma. This study performs a drug-free approach by encapsulating black phosphorus (BP) and calcium peroxide (CaO2) in liposomes with surface-modified triphenylphosphonium (BCLT) to develop mitochondria targeting calcification for cancer therapy without damaging normal cells. BCLT preferentially accumulates inside tumor mitochondria and then is activated by near-infrared (NIR) laser irradiation to produce abundant PO4 3- and Ca2+ to accelerate in situ mitochondrial mineralization, leading to mitochondrial dysfunction and cancer cell death. More importantly, both PO4 3- and Ca2+ are essential components of metabolism in the body, and random gradient diffusion or premature leakage does not cause damage to adjacent normal cells. This achievement promises to be an alternative to conventional chemotherapy in clinical practice for many specific tumor types.
author2 School of Chemistry, Chemical Engineering and Biotechnology
author_facet School of Chemistry, Chemical Engineering and Biotechnology
Ma, Zhaoyu
Zeng, Pei
Zhai, Tianyou
Zhao, Yanli
Liang, Huageng
format Article
author Ma, Zhaoyu
Zeng, Pei
Zhai, Tianyou
Zhao, Yanli
Liang, Huageng
author_sort Ma, Zhaoyu
title In situ mitochondrial biomineralization for drug-free cancer therapy
title_short In situ mitochondrial biomineralization for drug-free cancer therapy
title_full In situ mitochondrial biomineralization for drug-free cancer therapy
title_fullStr In situ mitochondrial biomineralization for drug-free cancer therapy
title_full_unstemmed In situ mitochondrial biomineralization for drug-free cancer therapy
title_sort in situ mitochondrial biomineralization for drug-free cancer therapy
publishDate 2024
url https://hdl.handle.net/10356/177912
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