Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model

• Main Authors: Obaldía, Nicanor, Da Silva Filho, Joao Luiz, Núñez, Marlon, Glass, Katherine A., Oulton, Tate, Achcar, Fiona, Wirjanata, Grennady, Duraisingh, Manoj, Felgner, Philip, Tetteh, Kevin Ka, Bozdech, Zbynek, Otto, Thomas D., Marti, Matthias
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Aotidae; Malaria
• Online Access: https://hdl.handle.net/10356/178486
• Institution: Nanyang Technological University

The malaria parasite Plasmodium vivax remains a major global public health challenge, and no vaccine is approved for use in humans. Here, we assessed whether P. vivax strain-transcendent immunity can be achieved by repeated infection in Aotus monkeys. Sterile immunity was achieved after two homologo...