Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848

Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848

About 247 million cases of malaria occurred in 2021 with Plasmodium falciparum accounting for the majority of 619,000 deaths. In the absence of a widely available vaccine, chemotherapy remains crucial to prevent, treat, and contain the disease. The efficacy of several drugs currently used in the cli...

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Bibliographic Details
Main Authors: Chung, Zara, Lin, Jianqing, Wirjanata, Grennady, Dziekan, Jerzy Michal, El Sahili, Abbas, Preiser, Peter Rainer, Bozdech, Zbynek, Lescar, Julien
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Malaria
Enzyme inhibition
Online Access:https://hdl.handle.net/10356/174722
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/174722

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