Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use. Decreasing responsiveness to antimalarial treatments stresses the need for a better resolved understanding of their MoAs and associated resistance mechanisms. In the present work, we implemented the cellular t...

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Bibliographic Details
Main Authors: Dziekan, Jerzy Michal, Yu, Han, Chen, Dan, Dai, Lingyun, Wirjanata, Grennady, Larsson, Andreas, Prabhu, Nayana, Sobota, Radoslaw Mikolaj, Bozdech, Zbynek, Nordlund, Pär
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Biological sciences
Biological Assay
Mefloquine
Molecular
Online Access:https://hdl.handle.net/10356/152477
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/152477

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