Access to axially chiral aryl aldehydes via carbene-catalyzed nitrile formation and desymmetrization reaction

Access to axially chiral aryl aldehydes via carbene-catalyzed nitrile formation and desymmetrization reaction

An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can...

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Bibliographic Details
Main Authors: Cai, Yuanlin, Lv, Ya, Shu, Liangzhen, Jin, Zhichao, Chi, Robin Yonggui, Li, Tingting
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2024
Subjects:
Chemistry
Engineering
Cyanides
Organic chemistry
Online Access:https://hdl.handle.net/10356/179793
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/179793

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