Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer

• Main Authors: Mishra, Alok K., Ye, Tianyi, Banday, Shahid, Thakare, Ritesh P., Su, Chinh Tran-To, Pham, Ngoc N. H., Ali, Amjad, Kulshreshtha, Ankur, Chowdhury, Shreya Roy, Simone, Tessa M., Hu, Kai, Zhu, Lihua Julie, Eisenhaber, Birgit, Deibler, Sara K., Simin, Karl, Thompson, Paul R., Kelliher, Michelle A., Eisenhaber, Frank, Malonia, Sunil K., Green, Michael R.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Aminopeptidase inhibitors; Bestatin
• Online Access: https://hdl.handle.net/10356/179820
• Institution: Nanyang Technological University

CD24 is frequently overexpressed in ovarian cancer and promotes immune evasion by interacting with its receptor Siglec10, present on tumor-associated macrophages, providing a "don't eat me" signal that prevents targeting and phagocytosis by macrophages. Factors promoting CD24 expressi...