Comparison of ligands in palladium-catalyzed electrochemical allyl 4-pyridinylation

Comparison of ligands in palladium-catalyzed electrochemical allyl 4-pyridinylation

4-CN-pyridine is a widely applied 4-pyridinylation reagent for diverse transformations. Conventionally, the reaction proceeds via an open-shell radical cross-coupling pathway. Following our previous study, in this work, we report the Pd-catalyzed allyl 4-pyrinylation reaction under electrochemical c...

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Bibliographic Details
Main Authors: Ding, Wei-Jie, Yang, Chun-Hui, Feng, Zhongtao, Lu, Shi-Rong, Cheng, Xu
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2024
Subjects:
Chemistry
Electrochemistry
Palladium
Online Access:https://hdl.handle.net/10356/179900
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Institution: Nanyang Technological University
Language: English
Description
Summary:4-CN-pyridine is a widely applied 4-pyridinylation reagent for diverse transformations. Conventionally, the reaction proceeds via an open-shell radical cross-coupling pathway. Following our previous study, in this work, we report the Pd-catalyzed allyl 4-pyrinylation reaction under electrochemical conditions. The reaction proceeds via radical-polar crossover pathway in which the role of phosphine ligand in reactivity and selectivity was extensively investigated.

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