Three-component Friedel-Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(iii) electrophile

• Main Authors: Kikuchi, Jun, Nagata, Toya, Ito, Shingo, Yoshikai, Naohiko
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Difunctionalization; Electrophiles
• Online Access: https://hdl.handle.net/10356/180049
• Institution: Nanyang Technological University

The three-component Friedel-Crafts type functionalization of an electron-rich arene using an electrophile-activated alkyne can offer a strategy for rapidly constructing densely functionalized vinylarenes in a regio- and stereoselective fashion. An analogous process utilizing ynamides, a distinct cla...