Spatial proteomics of immune microenvironment in nonalcoholic steatohepatitis-associated hepatocellular carcinoma

• Main Authors: Li, Meiyi, Wang, Lina, Cong, Liang, Wong, Chi Chun, Zhang, Xiang, Chen, Huarong, Zeng, Tao, Li, Bin, Jia, Xian, Huo, Jihui, Huang, Yuhua, Ren, Xiaoxue, Peng, Sui, Fu, Guo, Xu, Lixia, Sung, Joseph Jao Yiu, Kuang, Ming, Li, Xiaoxing, Yu, Jun
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Liver tumor; Hepatocellular
• Online Access: https://hdl.handle.net/10356/180080
• Institution: Nanyang Technological University

Background and Aims: NASH-HCC is inherently resistant to immune checkpoint blockade, but its tumor immune microenvironment is largely unknown. Approach and Results: We applied the imaging mass cytometry to construct a spatially resolved single-cell atlas from the formalin-fixed and paraffin-embedded...