TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in triple-negative breast cancer

• Main Authors: Sim, Nicholas, Carter, Jean-Michel, Deka, Kamalakshi, Tan, Benita Kiat Tee, Sim, Yirong, Tan, Suet-Mien, Li, Yinghui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Carcinogenesis; Breast cancer cell line
• Online Access: https://hdl.handle.net/10356/180403
• Institution: Nanyang Technological University

Triple Negative Breast Cancer (TNBC) is the most aggressive breast cancer subtype suffering from limited targeted treatment options. Following recent reports correlating Fibroblast growth factor-inducible 14 (Fn14) receptor overexpression in Estrogen Receptor (ER)-negative breast cancers with metast...