PRPF40A induces inclusion of exons in GC-rich regions important for human myeloid cell differentiation

PRPF40A induces inclusion of exons in GC-rich regions important for human myeloid cell differentiation

We characterized the regulatory mechanisms and role in human myeloid cell survival and differentiation of PRPF40A, a splicing factor lacking a canonical RNA Binding Domain. Upon PRPF40A knockdown, HL-60 cells displayed increased cell death, decreased proliferation and slight differentiation phenotyp...

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Bibliographic Details
Main Authors: Tan, Cheryl Weiqi, Sim, Donald Yuhui, Zhen, Yashu, Tian, Haobo, Koh, Jace, Roca, Xavier
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Bone marrow cell
Cell death
Online Access:https://hdl.handle.net/10356/180501
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/180501

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