PRPF40A induces inclusion of exons in GC-rich regions important for human myeloid cell differentiation

• Main Authors: Tan, Cheryl Weiqi, Sim, Donald Yuhui, Zhen, Yashu, Tian, Haobo, Koh, Jace, Roca, Xavier
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Bone marrow cell; Cell death
• Online Access: https://hdl.handle.net/10356/180501
• Institution: Nanyang Technological University

We characterized the regulatory mechanisms and role in human myeloid cell survival and differentiation of PRPF40A, a splicing factor lacking a canonical RNA Binding Domain. Upon PRPF40A knockdown, HL-60 cells displayed increased cell death, decreased proliferation and slight differentiation phenotyp...