PRPF40A induces inclusion of exons in GC-rich regions important for human myeloid cell differentiation

• المؤلفون الرئيسيون: Tan, Cheryl Weiqi, Sim, Donald Yuhui, Zhen, Yashu, Tian, Haobo, Koh, Jace, Roca, Xavier
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Medicine, Health and Life Sciences; Bone marrow cell; Cell death
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/180501
• المؤسسة: Nanyang Technological University

We characterized the regulatory mechanisms and role in human myeloid cell survival and differentiation of PRPF40A, a splicing factor lacking a canonical RNA Binding Domain. Upon PRPF40A knockdown, HL-60 cells displayed increased cell death, decreased proliferation and slight differentiation phenotyp...