An enzymatic oxidation cascade converts δ-thiolactone anthracene to anthraquinone in the biosynthesis of anthraquinone-fused enediynes

An enzymatic oxidation cascade converts δ-thiolactone anthracene to anthraquinone in the biosynthesis of anthraquinone-fused enediynes

Anthraquinone-fused enediynes are anticancer natural products featuring a DNA-intercalating anthraquinone moiety. Despite recent insights into anthraquinone-fused enediyne (AQE) biosynthesis, the enzymatic steps involved in anthraquinone biogenesis remain to be elucidated. Through a combination of i...

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Bibliographic Details
Main Authors: Ma, Guang-Lei, Liu, Wan-Qiu, Huang, Huawei, Yan, Xin-Fu, Shen, Wei, Visitsatthawong, Surawit, Prakinee, Kridsadakorn, Tran, Hoa, Fan, Xiaohui, Gao, Yong-Gui, Chaiyen, Pimchai, Li, Jian, Liang, Zhao-Xun
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Anthraquinone formation
Enediynes
Online Access:https://hdl.handle.net/10356/180505
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/180505

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