27-hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior

27-hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior

Oxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize that 27HC...

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Main Authors: Hui, Ye, Yang, Xiaohua, Feng, Bing, Luo, Pei, Irizarry, Valeria C. Torres, Carrillo-Sáenz, Leslie, Yu, Meng, Yang, Yongjie, Eappen, Benjamin P., Munoz, Marcos David, Patel, Nirali, Schaul, Sarah, Ibrahimi, Lucas, Lai, Penghua, Qi, Xinyue, Zhou, Yuliang, Kota, Maya, Dixit, Devin, Mun, Madeline, Liew, Chong Wee, Jiang, Yuwei, Wang, Chunmei, He, Yanlin, Xu, Pingwen
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Arcuate nucleus
Blood-brain barrier
Online Access:https://hdl.handle.net/10356/180576
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/180576

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