27-hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior

• Main Authors: Hui, Ye, Yang, Xiaohua, Feng, Bing, Luo, Pei, Irizarry, Valeria C. Torres, Carrillo-Sáenz, Leslie, Yu, Meng, Yang, Yongjie, Eappen, Benjamin P., Munoz, Marcos David, Patel, Nirali, Schaul, Sarah, Ibrahimi, Lucas, Lai, Penghua, Qi, Xinyue, Zhou, Yuliang, Kota, Maya, Dixit, Devin, Mun, Madeline, Liew, Chong Wee, Jiang, Yuwei, Wang, Chunmei, He, Yanlin, Xu, Pingwen
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Arcuate nucleus; Blood-brain barrier
• Online Access: https://hdl.handle.net/10356/180576
• Institution: Nanyang Technological University

Oxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize that 27HC...