27-hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior

• المؤلفون الرئيسيون: Hui, Ye, Yang, Xiaohua, Feng, Bing, Luo, Pei, Irizarry, Valeria C. Torres, Carrillo-Sáenz, Leslie, Yu, Meng, Yang, Yongjie, Eappen, Benjamin P., Munoz, Marcos David, Patel, Nirali, Schaul, Sarah, Ibrahimi, Lucas, Lai, Penghua, Qi, Xinyue, Zhou, Yuliang, Kota, Maya, Dixit, Devin, Mun, Madeline, Liew, Chong Wee, Jiang, Yuwei, Wang, Chunmei, He, Yanlin, Xu, Pingwen
• مؤلفون آخرون: School of Chemistry, Chemical Engineering and Biotechnology
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Medicine, Health and Life Sciences; Arcuate nucleus; Blood-brain barrier
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/180576

Oxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize that 27HC...