Assessing nanotoxicity of food-relevant particles: a comparative analysis of cellular responses in cell monolayers versus 3D gut epithelial cultures

• Main Authors: Gautam, Archana, Lim, Hui Kheng, Li, Jasmine Jia’En, Hughes, Christopher Owen, Yeo, Calvin Wee Sing, Rakshit, Moumita, Leavesley, David Ian, Lim, Michelle Jing Sin, Tan, Joseph Choon Wee, Tan, Li Yi, Chan, Joanne Sheot Harn, Smith, Benjamin Paul Chapman, Ng, Kee Woei
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Nanoparticles; Nanotoxicology; Intestine; Genotoxicity; 3D models
• Online Access: https://hdl.handle.net/10356/180595
• Institution: Nanyang Technological University

Engineered nanoparticles (NPs) are extensively used in the food industry, yet safety concerns remain. The lack of validated methodologies is a bottleneck towards resolving this uncertainty. Hence, the current study aims to compare two cell models by examining the toxicological impacts of two food-re...