Cellular uptake of phase-separating peptide coacervates

• Main Authors: Shebanova, Anastasia, Perrin, Quentin Moana, Zhu, Kexin, Gudlur, Sushanth, Chen, Zilin, Sun, Yue, Huang, Congxi, Lim, Zhi Wei, Mondarte, Evan Angelo, Sun, Ruoxuan, Lim, Sierin, Yu, Jing, Miao, Yansong, Parikh, Atul N., Ludwig, Alexander, Miserez, Ali
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Cell uptake; Drug delivery
• Online Access: https://hdl.handle.net/10356/180615
• Institution: Nanyang Technological University

Peptide coacervates self-assembling via liquid-liquid phase separation are appealing intracellular delivery vehicles of macromolecular therapeutics (proteins, DNA, mRNA) owing to their non-cytotoxicity, high encapsulation capacity, and efficient cellular uptake. However, the mechanisms by which thes...