Carbonyl group-assisted 1,3-amine addition to α,β-unsaturated aldehydes

• Main Authors: Zhang, Zhenguo, Ren, Mi, Lu, Ming-Zhu, Jia, Zhenhua, Loh, Teck-Peng
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Engineering; Unsaturated α-amino acetals; Iodine
• Online Access: https://hdl.handle.net/10356/180627
• Institution: Nanyang Technological University

An unusual 1,3-addition products were obtained when amines were reacted with α,β-unsaturated aldehydes compounds in the presence of iodine and an oxidant. The versatile unsaturated α-amino acetals are highly useful amino acid derivatives and can be converted to a wide variety of synthetically useful...