Characterizing the alphavirus replication complex to develop antivirals and next generation self-amplifying RNA based therapeutics

• Main Author: Law, Michelle Cheok Yien
• Other Authors: Franklin Zhong Lei
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2024
• Subjects: Medicine, Health and Life Sciences; RNA virus; Alphavirus; Self-amplifying RNA; Antivirals; 5' cap
• Online Access: https://hdl.handle.net/10356/180674
• Institution: Nanyang Technological University

Alphaviruses such as chikungunya virus and Venezuelan equine encephalitis virus are medically relevant pathogens which can affect human health and disease with no approved therapies. They are enveloped viruses which contain a single stranded positive sense RNA genome. The genome is approximately 11-...