Dual p38MAPK and MEK inhibition disrupts adaptive chemoresistance in mesenchymal glioblastoma to temozolomide

• Main Authors: Cheng, Hong Sheng, Chong, Yuk Kien, Lim, Eldeen Kai Yi, Lee, Xin Yi, Pang, Qing You, Novera, Wisna, Marvalim, Charlie, Lee, Jeannie Xue Ting, Ang, Beng Ti, Tang, Carol, Tan, Nguan Soon
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Brain cancer; Glioma
• Online Access: https://hdl.handle.net/10356/180688
• Institution: Nanyang Technological University

Background: Precision treatment of glioblastoma is increasingly focused on molecular subtyping, with the mesenchymal subtype particularly resistant to temozolomide. Here, we aim to develop a targeted therapy for temozolomide resensitization in the mesenchymal subtype. Methods: We integrated kinomic...