3D printed biomimetic composite scaffolds with sequential releasing of copper ions and dexamethasone for cascade regulation of angiogenesis and osteogenesis

• Main Authors: Song, Yongteng, Hu, Qingxi, Liu, Suihong, Wang, Yahao, Jia, Lijun, Hu, Xinli, Huang, Changjin, Zhang, Haiguang
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Engineering; Large bone defect repair; Vascularized bone scaffold
• Online Access: https://hdl.handle.net/10356/180767
• Institution: Nanyang Technological University

Repairing bone defects is a complex multi-stage physiological process involving the coupling of early angiogenesis and later osteogenesis and is often complicated by infection, therefore, this process remains a major clinical problem. Although functional drug-loaded engineered scaffolds are promisin...