pH-dependent interactions of coacervate-forming histidine-rich peptide with model lipid membranes

• Main Authors: Gudlur, Sushanth, Ferreira, Filipe Viana, Ting, Javier Shu Ming, Domene, Carmen, Maricar, Syed, Le Brun, Anton P., Yepuri, Nageshwar, Moir, Michael, Russell, Robert, Darwish, Tamim, Miserez, Ali, Cárdenas, Marité
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Peptide coacervates; Neutron reflectivity
• Online Access: https://hdl.handle.net/10356/180813
• Institution: Nanyang Technological University

Peptide-based liquid droplets (coacervates) produced by spontaneous liquid-liquid phase separation (LLPS), have emerged as a promising class of drug delivery systems due to their high entrapping efficiency and the simplicity of their formulation. However, the detailed mechanisms governing their inte...